Welcome to the webinar archive, which features presentations about current scientific and policy topics related to computational and in vitro toxicology. These videos are recorded as part of the ASCCT/ESTIV monthly webinar series, sponsored by ASCCT and theEuropean Society for Toxicology In Vitro. They are organized by year using the horizontal menu below. Please feel free to view any webinar; you can search for key words in the search bar at the top of the page.
You can also view all of the webinars on our YouTube channel. To find out about the next webinar, visit the calendar of events on the right side of the screen.
Finally, if you have ideas for upcoming webinars, please share them in the member Community Forum or by emailing[email protected].
Advances in Genotoxicity: Reconstructed Skin Comet and Micronucleus Assays (January 2022)
Presenters: Stefan Pfuhler, Procter and Gamble (slides) Kerstin Reisinger, Henkel AG & Co. KGaA (slides)
Serum-Free Cultures: Why and How? (February 2022)
Presenters: Barbara Jozef, PhD, Swiss Federal Institute of Aquatic Science and Technology (EAWAG) Aline Chary, PhD, Luxembourg Institute of Science and Technology (LIST)
Additional resources:
Van der Valk, J., Brunner, D., De Smet, K. et al. (2010). Optimization of chemically defined cell culture media – Replacing fetal bovine serum in mammalian in vitro methods. Toxicology in Vitro 24, 1053–1063. https://doi.org/10.1016/j.tiv.2010.03.016
Maturing three-dimensional toxicology models of the barrier organs: Examples from lung and skin (March 2022)
Presenters: Patrícia Zoio, PhD candidate, Institute of Chemical and Biological Technology, NOVA University of Lisbon (slides) Sabrina Madiedo-Podvršan, PhD candidate, Université de Technologie de Compiègne (UTC) Samuel Constant, PhD, CEO, Epithelix (slides)
Development and evaluation of NAMs for new endpoints: Developmental neurotoxicity and respiratory sensitization (April 2022)
Presenters: Sabina Burla, Luxembourg Institute of Science and Technology (LIST) Kelly Carstens, PhD, US EPA (slides)
Additional resources:
Carstens, Kelly E, Amy F Carpenter, Melissa M Martin, Joshua A Harrill, Timothy J Shafer, and Katie Paul Friedman. “Integrating Data from in Vitro New Approach Methodologies for Developmental Neurotoxicity.” Toxicological Sciences, 2022. https://doi.org/10.1093/toxsci/kfac018.
Chary, Aline, Tommaso Serchi, Elisa Moschini, Jennifer Hennen, Sébastien Cambier, Janine Ezendam, Brunhilde Blömeke, and Arno C. Gutleb. 2019. “An in Vitro Coculture System for the Detection of Sensitization Following Aerosol Exposure”. ALTEX - Alternatives to Animal Experimentation 36 (3):403-18. https://doi.org/10.14573/altex.1901241
Advancing In Vitro Models for Genotoxicity and Carcinogenicity (May 2022)
Presenters: Anouck Thienpoint, PhD student, Laboratory of In Vitro Toxicology and Dermato-Cosmetology Silvia Scaglione, React4life, ESTIV corporate member
ASCCT-ESTIV special webinar for Ukraine: Science for Policy, Policy for Science (June 2022)
Speakers: Kristie Sullivan, MPH, Physicians Committee for Responsible Medicine (slides) Francois Busquet, PhD, Altertox (slides) Nataliia Bubalo, PhD, National University of Food Technologies, Ukraine (slides)
Guidance and standards for increasing regulatory confidence in in vitro and PBK models (July 2022)
Presenters: Alicia Paini, PhD, ERT, esqLABS (slides) Amanda Ulrey, RQAP-GLP, Institute for In Vitro Sciences, Inc. (IIVS) (slides)
Modeling tools for better prediction of the kinetics and dynamics of xenobiotics (August 2022)
Presenters: Luca Dellafiora, PhD, University of Parma Department of Food and Drug (slides) Nynke L. Kramer, PhD, Wageningen University Toxicology Division (slides)
Using NAMs in Risk Assessment (September 2022)
Presenters: Katie Paul Friedman, PhD, Center for Computational Toxicology and Exposure, Office of Research and Development, US EPA George E. N. Kass, PhD, European Food Safety Authority (EFSA) (slides)
Astuto, M.C. et al. (2022). In Silico Methods for Environmental Risk Assessment: Principles, Tiered Approaches, Applications, and Future Perspectives. In: Benfenati, E. (eds) In Silico Methods for Predicting Drug Toxicity. Methods in Molecular Biology, vol 2425. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1960-5_23
Carl Westmoreland, Hans J. Bender, John E. Doe, Miriam N. Jacobs, George E.N. Kass, Federica Madia, Catherine Mahony, Irene Manou, Gavin Maxwell, Pilar Prieto, Rob Roggeband, Tomasz Sobanski, Katrin Schütte, Andrew P. Worth, Zvonimir Zvonar, Mark T.D. Cronin, Use of New Approach Methodologies (NAMs) in regulatory decisions for chemical safety: Report from an EPAA Deep Dive Workshop, Regulatory Toxicology and Pharmacology, Volume 135, 2022, 105261, ISSN 0273-2300, https://doi.org/10.1016/j.yrtph.2022.105261.
Ly Ly Pham, Sean M. Watford, Prachi Pradeep, Matthew T. Martin, Russell S. Thomas, Richard S. Judson, R. Woodrow Setzer, Katie Paul Friedman, Variability in in vivo studies: Defining the upper limit of performance for predictions of systemic effect levels, Computational Toxicology, Volume 15, 2020, 100126, ISSN 2468-1113, https://doi.org/10.1016/j.comtox.2020.100126.
Prachi Pradeep, Katie Paul Friedman, Richard Judson, Structure-based QSAR models to predict repeat dose toxicity points of departure, Computational Toxicology, Volume 16, 2020, 100139, ISSN 2468-1113, https://doi.org/10.1016/j.comtox.2020.100139.
Serafimova R, Coja T and Kass GEN (2021) Application of the Threshold of Toxicological Concern (TTC) in Food Safety: Challenges and Opportunities. Front. Toxicol. 3:655951. doi: 10.3389/ftox.2021.655951
Tools & Recommendations for Improving Peer Review in the Scientific Literature(December 2022)
Presenters: Paul Whaley, PhD, Evidence-Based Toxicology Collaboration (slides) Sofia Batista Leite, PhD, European Commission, Joint Research Centre (slides)
