REGISTER NOW FOR WEBINAR 1

10:00 am ET / 15:00 UTC

This webinar series is co-organised by PETA Science Consortium International and the Institute for In Vitro Sciences.

Victoria Hull, Senior Bioinformatician, Inotiv

This interactive module comprises three webinars and will provide participants with foundational knowledge needed to interpret and apply computational workflows in modern toxicology. Webinars will focus on seven in silico approaches that are commonly used for chemical hazard characterisation and risk assessment: 1) quantitative structure-activity relationship (QSAR); 2) read-across; 3) physiologically-based pharmacokinetic (PBPK) modeling; 4) in vitro to in vivo extrapolation (IVIVE); 5) quantitative adverse outcome pathway (qAOP); 6) molecular modeling; and 7) machine/deep learning and artificial intelligence (AI).

The first webinar will provide a brief history of the use of in silico models for chemical hazard characterisation, as well as current applications and status in regulatory frameworks. The second and third webinars will introduce the fundamentals of the seven in silico approaches, including their purpose, inputs, outputs, and basic information flow. Brief case studies will be presented to illustrate how each in silico approach can complement or replace in vitro and in vivo data to strengthen weight-of-evidence evaluations.

After attending this webinar, participants will be able to:

• Describe some current uses of in silico tools and the state of their acceptance for regulatory applications.
• Explain how in silico models can complement other data sources for chemical hazard characterisation.
• Define important terms used to describe various aspects of in silico models.
• List the purpose, inputs and outputs, and basic flow of information for common in silico tools.

The recording of this webinar and the accompanying slide deck, along with details on THE additional webinars in Module 1 will be posted to https://www.thepsci.eu/in-silico-tools-webinars/.